Combining Psilocybin and Antidepressants (SSRIs, etc.)
By Erica Zelfand

What does psilocybin-assisted therapy look like when clients enter the clinic on antidepressant medication?

Common practice is to tell patients on SSRIs and other prescription drugs that they must stop taking their psychiatric medications before they can safely take psilocybin, but neither anecdotal evidence nor the scientific literature support this. Researchers and practitioners alike are eager to find effective evidence-based treatment to assist people with anxiety, depression, and other disorders that require pharmaceutical intervention.

Psychedelic Support hosted this conversation on May 13th, 2022 with integrative mental health professional and psychedelic facilitator, Dr. Erica Zelfand. We explored the the interplay between antidepressant medications and psilocybin. We reviewed the pharmacology of these substances and consider new research on how clinicians can understand and utilize modern psychedelic research to assist clients.